Glad to share Dr. Sebastien Piluso's work on the
new atlas version paper, emerging from a long-standing research effort
at the Blue Brain Project, is officially out in Imaging Neuroscience!
https://lnkd.in/dGdYhWyC
This
work not only presents the first atlas covering the mouse central
nervous system, but also provides anatomical reference data that unlock
precise atlas segmentation of experimental brain images.
We even aim to shift the conceptualization of brain atlases from a single-volume reference model to a more versatile, next-generation framework.
This paves the way for large-scale brain image segmentation and the automated analysis of massive datasets using efficient, automated, and reproducible tools.
To showcase the capabilities of this dataset, we generated the first cellular atlas of the entire mouse brain, automatically identifying the coordinates, anatomical regions, and cell types of all its ~70 million constituent neurons. Additionally, we created an isotropic 10 μm-resolution average Nissl template from over 80,000 histological sections, revealing unprecedented anatomical contrasts without using interpolation.
Finally, these data serve as the foundational basis for constructing a precise and generic model of a digital mouse brain, now maintained by the Open Brain Institute. We have succeeded in bridging both ends by converting post-mortem anatomical images directly into realistic in silico data, which represents a significant step forward in the field of brain simulation.
Do not hesitate to explore, use, and share widely with colleagues!
I would like to thank all those who contributed to this work, and give a special thank you to Cyrille Favreau for the wonderful image visualization and Karin Holm for invaluable editorial support!
